Manuel was born about 1150, the son of unknown parents. The place is not known.
His wife was Ioanna Phokaina Karatzaina. They were married, but the date and place have not been found. Their six known children were Théodore I (1173-1222), Constantine (?-1205), Manuel (?-<1271), Georgios (?-?), Alexios (?-?) and Isaakios (?-?).
| Event | Date | Details | Source | Multimedia | Notes |
|---|---|---|---|---|---|
| Birth | ABT 1150 |
|