Isaac was the son of unknown parents. The date and place of his birth have not been found.
His wife was Anna Komnene Angelina, who he married in BEF 1195. The place has not been found. They had no known children.
| Attribute | Date | Description | Details | Source | Multimedia | Notes |
|---|---|---|---|---|---|---|
| Nobility Title | sebastokratōr |
| Association | Relationship |
|---|---|
| Manuel I Komnenos (Αυτοκράτορας του Βυζαντίου (emperor of Byzantium)) | great-uncle |