Margareta was the daughter of unknown parents. The date and place of her birth have not been found.
Her husband was Wilhelm III von Wolfstein. They were married, but the date and place have not been found. Their ten known children were Adam (?-1547), Gottfried (1449-1556), Johann IV (1501-1558), Bernhard (?-1561), Wilhelm (?-?), Johann (?-?), Eglof (?-?), Kunigunde (?-?), Anna (?-1523) and Eva (?-?).