Lijsabeth was the daughter of unknown parents. The date and place of her birth have not been found.
Her partner was Reinoud II van Brederode, but they were never married. Their seven known children were Walraven (1440-?), Johan (1442-?), Reinier (1444-1481), Hendrik (1447-?), Johan (1450-?), Johanna (1455-?) and Joost (1457-?).