Ursula was the daughter of George St. Barbe but her mother is unknown. The date and place of her birth have not been found.
Her husband was sir William Ussher, who she married on 14 MAY 1645. The place has not been found. Their seven known children were Mary (?-?), William (?-1647), Arthur (?-?), Henry (?-1658), Frances (?-?), John (1646-1745) and venerable Adam (1650-1713).