Mihály was the son of Pál Vay de Vaja Ibrány but his mother is unknown. The date and place of his birth have not been found.
His wife was Anna Szénás. They were married, but the date and place have not been found. Their six known children were Demeter (?-<1563), László (?-?), Antal (<1524-<1574), Tamás (?-?), Péter (?-<1570) and Katalin (?-?).