Margareta was the daughter of Georg von Edelsheim but her mother is unknown. The date and place of her birth have not been found.
She had two marriages/partners. Her first partner was Maximilian I von Habsburg, but they were never married. Their two known children were Barbara (1500-1550) and Georg (1504-1557).
Her second husband was Johann von Hylla. They were married, but the date and place have not been found. They had no known children.